New test claims to measure biological age and even predict time of death
Researchers from Harvard Medical School have developed a test that uses gene activity patterns to estimate biological age and time to death. Science writer Helen Pilcher explains why she would rather not take it, citing the potential for negative beliefs to harm health.
A new molecular clock
A team led by Vadim Gladyshev at Harvard Medical School has created a new test that not only measures biological age but also provides an estimate of time to death. Unlike earlier clocks based on epigenetic markers, this one analyzes patterns of gene activity from over 4,000 humans as well as data from mice, rats, and macaques. The researchers believe it is more sensitive than previous methods, such as the Horvath clock.
Purpose and potential
The test could shorten clinical trials for anti-aging therapies by providing a reliable measure of aging. It might also inform age-related policies, which currently rely on chronological age. If the tests prove accurate, future policies could be adjusted to account for individual differences in biological aging.
Why some would avoid it
Science writer Helen Pilcher, author of This Book May Cause Side Effects, argues she wouldn't take the test even if it became publicly available. She notes that such tests offer probability estimates, not definitive predictions. Moreover, citing research by Becca Levy at Yale University, she warns that negative expectations about aging can become biologically embodied, leading to earlier death. Levy's study found that people with a negative view of aging died on average 7.5 years earlier than those with positive views. Pilcher prefers to maintain a rosy outlook and avoid anything that might challenge it.
Current status
The test is currently for research use only, but a commercial version may follow. The Kardashians have already taken a similar commercial test; Khloé, then 39, learned her biological age was 28.
