Scientists look to genes for the secret of 194-year-old tortoise Jonathan's long life
Researchers compared the DNA of Jonathan the tortoise with other tortoises' genes and found unique genetic and epigenetic features that may explain his 194-year life. The findings could also help in understanding human ageing.
Scientists studying the DNA of a tortoise named Jonathan may be closer to explaining why he has lived so long. Jonathan, who is 194 years old, is the oldest living land animal. The research could provide useful information about the mechanisms of longevity, including how ageing might be slowed in humans, according to the portal Live Science.
What the researchers compared
The researchers compared samples of Jonathan's DNA with the genes of other tortoises and identified several unique genetic and epigenetic features. Epigenetic markers are chemical tags on DNA molecules. They help regulate which genes are switched on and how strongly.
The analysis shows that Jonathan's genes linked to the function of mitochondria are in excellent epigenetic condition. This suggests they may have played an important role in his long life.
Gene variants linked to ageing
The team also found 287 unique gene variants associated with ageing processes. Among them are genes involved in repairing damaged DNA. Others support the function of telomeres, the protective caps at the ends of chromosomes.
The authors believe the tortoise may carry rare gene variants that slow the wearing down of telomeres. That would better protect him from the symptoms of ageing.
If this assumption is confirmed, science could gain useful information about longevity. It might also help extend human lifespan.
